Yohimbine
Yohimbine, ib qho alpha-2 adrenergic receptor antagonist, yog ib qho ntawm cov khoom lag luam uas nrov tshaj plaws hauv kev npaj ua ntej, rog-hlawv, thiab kev noj zaub mov zoo. Yohimbine pabcuam kev noj tshuaj yog siv rau ntau lub hom phiaj, suav nrog tab sis tsis txwv rau txhawb kev poob phaus thiab kho erectile kawg (ED). Yohimbine yog qhov sib luag los kho cov teeb meem kev sib deev uas yog los ntawm kev kho mob siab ntsws uas yog hu ua selective-serotonin reuptake inhibitors (SSRIs). Nws kuj tseem siv los ntawm cov kis las thiab cov neeg tawm dag zog kom txhim kho kev ua tau zoo thiab Yohimbine kuj tseem paub los txo cov kev ntshai uas cuam tshuam nrog qee yam phobias.
Kev Siv Tes Haujlwm Ntawm Yohimbine
Yohimbine inhibits alpha-1 thiab alpha-2 adrenoceptors, txo cov qib serotonin, thiab nce qib ntawm dopamine thiab adrenaline. Nws kuj tseem paub txog yuav txo cov ntshav qab zib cov ntshav, tso tawm cov insulin, thiab ua rau cov ntshav siab ntxiv. Nws ua rau lub qhov txhab ntawm cov hlab ntsha thiab cov hlab ntaws tshiab xa mus rau cov ntaub so ntswg ntawm qhov chaw mos. Yohimbine kuj tseem paub los txhim kho reflex excitability hauv thaj av ntawm sacral ntawm txha caj qaum. Nws yog txhua tus paub zoo rau nws cov serotonin receptor thaiv, calcium channel thaiv, thiab monoamine oxidase inhibiting cov teebmeem.
Yohimbine inhibits presynaptic alpha-2 adrenergic receptors ntau ntawm cov kab ntawm Reserpine tab sis nws qhov kev nqis tes ua rau lub sijhawm luv dua thiab qaug zog. Lub peripheral autonomic lub paj hlwb nyhuv ntawm Yohimbine yog kom txo qis kev sib cav sib luag (adrenergic) thiab nce kev ua haujlwm parasympathetic (cholinergic). Nws yog qhov tsim nyog kom nco ntsoov ntawm no tias kev txhim kho hauv txiv neej kev sib deev yog txuam nrog cholinergic kev ua si thiab rau alpha-2 adrenergic blockade uas tuaj yeem ua rau txo qis lossis nce rab qau nplua, lossis ob qho tib si.
Kev tshem tawm ntawm cov tawv ncauj subcutaneous rog cov khw muag khoom noj kom koj cov zaub mov noj kom tsawg yog feem ntau nyuaj vim tias muaj ntau cov laj thawj. Tsis muaj qhov xav tias peb feem ntau pom muaj qee qhov chaw "tawv ncauj" lossis tsis yooj yim muab cov rog rog [feem ntau ua rau qis qis, qis dua, thiab lub duav rau cov txiv neej thiab txhais ceg thiab lub duav rau cov poj niam]. Ntau dua qhov tsis tau, qhov no yog vim muaj qhov muaj peev xwm suav ntau ntawm Alpha-2 Txais Txais hauv cov roj ntsha uas qhia lub cev kom tuav cov rog nyob hauv cov chaw no rau kev ua kom nyob taus. Yohimbine inhibits cov Alpha-2 Receptors thiab yog li tua cov lus los khaws cov roj ntsha tawv ntawd. Nws kuj tseem tso cov rog tawm rau oxidisation (hlawv).
Cov Kev Sib Tw Enzymatic
Yohimbine muaj lub peev xwm los cuam tshuam nrog CYP2D6 enzyme thiab inhibit nws txoj haujlwm. Kev soj ntsuam ntsuas Ki tau pom qhov pom tseeb ntawm Ki ntawm 0.52uM rau kev ua kom huv CYP2D6 enzymes thiab 0.23uM rau microsomes. Qhov no txuas ntxiv rau Corynanthine nrog pom meej Ki ntawm 0.08uM. Nws yog ib qho tsim nyog kom nco ntsoov ntawm no tias qhov no yog tib qho enzyme uas metabolises Yohimbine mus rau 11-hydroxy Yohimbine thiab ua kom pom ntau dua 1000-ntau qhov sib txawv ntawm cov tib neeg raws CYP2D6 qhia genotype (muaj tsawg kev sib cuam tshuam nrog CYP3A4).
Cov txiaj ntsig ntawm Yohimbine
- Yohimbine pab ua kom tsis txhob muaj kev nyuaj siab.
- Nws pab tua cov rog plab tawv ncauj.
- Yohimbine txo cov rog rog yam tsis muaj kev cuam tshuam zoo rau lub cev nqaij daim tawv uas yog qhov tseem ceeb rau kev ua kom lub cev muaj pes tsawg leeg.
- Nws pab txhim kho kev tawm dag zog los ntawm kev ua kom lub cev qoj ib ce yog qhov zoo tshaj vim tias qhov kev ua haujlwm tawm dag zog tuaj yeem raug txo qis vim tias muaj calorie tsawg.
- Yohimbine ua rau cov metabolism ntxiv rau cov kev ua kom rog-zoo.
- Nws hloov kho txhim kho endurance thiab qib zog.
- Yohimbine yog thib ob rau qhov tsis muaj rau hlawv caj npab tawv ncauj, hlub ua haujlwm, glutes (taub qab), thiab rog rog hauv qab rog.
- Yohimbine ua haujlwm tau zoo raws li kev ua kom qab los noj mov zoo.
- Lub zog muaj zog tshaj plaws ntawm Yohimbine ua rau nws xaiv zoo rau cov neeg ncaws pob, rau thiab tawm sab nraud.
- Tsis tsuas yog qhov no, Yohimbine tseem ceeb nce cov ntsiab lus ntsuas ntawm kev txaus siab rau kev sib deev, kev muaj siab, ntau zaus ntawm kev sib daj sib deev, thiab qhov ua tau zoo ntawm erections thaum sib deev.
- Nws tseem ua tsis zoo rau ob qho tib si lub cev thiab kev mob tshwm sim uas feem ntau cuam tshuam nrog kev ua haujlwm erectile kawg.
Adrenergic Neurotransmission
Qhov feem ntau-kev tshawb nrhiav thiab thawj lub tshuab ntawm Yohimbine yog qhov tsis ua haujlwm (kev tsis haum xeeb) ntawm ib chav kawm ntawm cov receptors hu ua Alpha-2-Adrenergic receptors. Yohimbine inhibits cov autoreceoptors ntawm presynaptic noradrenergic neurons kom muaj kev tso tawm ntawm noradrenaline vim cov lus tsis zoo inhibition voj tau cuam tshuam.
Yohimbine Thiab Ntshai Ntsej Muag
Yohimbine muaj lub peev xwm tshwj xeeb los pab txhawb kev ntshai tsam ploj zuj zus uas yog qhov kev xav ntawm qhov kev xav uas qhov kev nthuav dav mus rau qhov kev ntshai tsis txaus ntseeg feem ntau ua rau desensitization rau qhov stimuli thiab txo lossis tshem tawm kev ntshai cuam tshuam nrog nws. Nws yog vim li no tias Yohimbine tau txuas nrog kev txhim kho kev ntshai ntog txuas ntxiv theem nrab rau kev kho kom zoo.
Yohimbine Thiab Rog Rog Poob
Yohimbine ua raws li adrenergic receptor system ntawm cov roj ntsha uas tswj cov thermogenesis. Cov beta-subunits ntawm adrenergic receptors, uas yog lub hom phiaj ntawm ephedrine, tau pom raws li cov rog poob stimulatory thaum lawv txhim kho cov kev ua ntawm Adenyl Cyclase (ib qho enzyme) thiab tom qab ntawd Cyclic adenosine monophosphate [(ib qho kev sib txuas ntawm adenosine triphosphate (ATP)] qib] Cov.
Nws yog qhov tsim nyog kom nco ntsoov ntawm no tias alpha-subunits yog ntau dua kev tiv thaiv ntawm cov txheej txheem ntawm cov rog rog. Yohimbine, yog xaiv cov tshuaj alpha-2 adrenergic receptor antagonist (inactivator), inhibits kev ua kom zoo ntawm cov tshuaj tiv thaiv receptor teeb thiab tshwj xeeb kev ua haujlwm ntawm Adenyl Cyclase thiab kev sib kho kom haum xeeb los ntawm beta receptors.
Yuav Ua Li Cas Noj Yohimbine?
Feem ntau, Yohimbine siv tau zoo tshaj plaws hauv kev siv tshuaj txhua hnub ntawm 0.2 mg rau ib phaus ntawm lub cev hnyav los hlawv cov rog. Qhov no txhais tau tias qhov ntau npaum ntawm 14mg rau 150lb ib tug neeg lossis 18 mg rau q 200lb ib tug neeg. Nws yog ib qho tseem ceeb kom nco ntsoov ntawm no tias Yohimbine pab ntxiv yog qhov zoo tshaj plaws thaum lub sijhawm yoo mov lossis nruab nrab ntawm cov pluas noj. Yog tias koj muaj kev ua xyem xyav los yog tsis meej pem hais txog qhov zoo tshaj plaws Yohimbine ntau npaum li cas, nws yog ib txwm zoo dua kom muaj lus nrog koj tus kws kho mob lossis chaw muag tshuaj ze tshaj li tsis noj cov tshuaj Yohimbine.
Qhov zoo tshaj plaws, Yohimbine yog qhov zoo tshaj plaws ua ntej ua ntej kev ceev cardio. Insulin blunts cov teebmeem ntawm Yohimbine ntawm Alpha-2 Receptors. Yog li, noj mov ze ntawm kev siv Yohimbine yuav tsis muaj txiaj ntsig thiab nws yog ib qho zoo taw rau yoo mov tsawg kawg 3-4 teev ua ntej kev siv Yohimbine. Qhov thib ob, cov rog yuav tsum raug hlawv tom qab Alpha-2 Receptors tau cuam tshuam. Qhov no txhais tau hais tias lub cev yuav tsum tau ua qee yam ntawm kev ua si thiab muaj tseeb tsis muaj kev ua haujlwm zoo tshaj li kev ua tiav ntawm lub xeev cardio.
Khoom Siv Yohimbine
Yohimbine tuaj yeem tawm pob nrog Xaiv Xaiv androgen receptor modulators nyiam Ostarine(MK-2866), Ibutamoren(MK-677), Andarine(S-4), LGD-4033, Thiab Cardarine(GW-501516).
Cov theem ntawm GW-501516 thiab Yohimbine yog qhov tshwj xeeb hauv ntau tshaj ib txoj kev. Cardarine yog qhov zoo tshaj plaws kom tau tob rau hauv kev npaj ua ntej thiab txhim kho kev ua kom tiav. Nws yog qhov zoo sib xws los txhawm rau tshem tawm cov kev xav ntawm kev hno thaum lub sij hawm ua haujlwm hnyav vim tias muaj ntau ntawm cov cardio thiab cov carbs qis. Hauv lwm lo lus, Cardarine pab koj ua reps ntxiv nrog rau hnyav rau hauv txoj kev zoo dua. Yog tias tsis yog txhua yam, nws hloov lub zog uas nyiam los ntawm lub cev los ntawm cov piam thaj (carbohydrates) rau cov rog uas txhais tau tias koj yuav hlawv cov roj ntau dua txhua hnub. Qhov no tseem yuav txhais tau tias yuav muaj ntau dua cov glycogen khaws cia rau kev ua haujlwm yav tom ntej. Ntawm qhov tod tes, Yohimbine twv yuav raug hu ntau dua li GW-501516.
Kev Tiv Thaiv Tsis Tseg / Ceev Faj
Yohimbine yog contraindicated rau cov tib neeg uas muaj keeb kwm kev kho mob ntawm lossis tam sim no tawm tsam nrog cov teeb meem kev noj qab haus huv xws li ntxhov siab vim, kev nyuaj siab, hypotension, angina, mob raum, lossis mob siab. Nws kuj tsis pom zoo kom cev xeeb tub lossis lactating poj niam thiab menyuam yaus. Kev siv Yohimbine yuav tsum ua tib zoo ua yog tias koj muaj kev mob ntshav qab zib, mob schizophrenia, kub siab, lossis benign prostatic hyperplasia.
Nws yog ib qho tseem ceeb kom nco ntsoov tias Yohimbine qhia tau cov txiaj ntsig zoo ntxiv nrog monoamine oxidase inhibitors. Yohimbine tuaj yeem txo lossis nce ntshav siab nrog tricyclic antidepressants.
Kev siv tshuaj ntawm Yohimbine yuav tsum tsis txhob nce lossis raug tsim txom lub sijhawm twg los ntawm kev cia siab ntawm cov txiaj ntsig tau sai. Kev tsim txom ntawm Yohimbine tuaj yeem ua rau phiv xws li khaus, kiv taub hau, thiab ua xua. Kev siv cov Yohimbine yuav tsum tau ua raws tas li kev sab laj ua ntej los ntawm kws kho mob.
Yuav Ua Li Cas Yohimbine?
Yog hais tias koj tab tom nrhiav rau yuav Yohimbine, Peb pom zoo xaiv tsuas yog tus muag muag Yohimbine zoo li tusSARMs KhwCov. Qhov no yooj yim vim tias muaj ntau qhov muag Yohimbine muag tawm sab nraud thiab tso siab rau lawv yuav txhais tau tias koj tsis tsuas yog poob ntawm koj cov nyiaj khwv tau los, tab sis kuj tseem ua rau koj lub cev rau cov khoom lag luam cuav, qis qis, lossis cov khoom lag luam me.
Txog qhov no, nws ib txwm pom zoo kom nyeem cov tshuaj xyuas, cov lus tawm tswv yim, cov lus pom zoo, thiab cov kev tsis txaus siab (yog tias muaj) los ntawm cov sib txawv hauv kev tawm dag zog thiab ntxiv cov ncauj lus. Qhov no yuav pab koj txheeb xyuas cov neeg muag khoom zoo tshaj plaws ntawm Yohimbine thiab xaiv cov tshuaj Yohimbine zoo tshaj plaws kom haum koj cov kev tsim kho lub cev, kev noj qab haus huv, thiab kev nyab xeeb, qhov xav tau. Tsis tas li ntawd, nws yuav pab koj txiav txim siab nyob hauv kev tiv thaiv tiv thaiv cov teeb meem ntawm Yohimbine kev tsim txom. Nco ntsoov, nws yog ib txwm zoo dua nyob ntawm kev tiv thaiv thiab siv Yohimbine rau koj cov kev xav tau ntxiv tsis muaj kev zam.